منابع مشابه
Perspectives on the therapeutic modulation of an alternative cell death, programmed necrosis (review).
In response to overwhelming external stimuli, cells are forced to die in different ways. By default, cells are prone to apoptosis, a programmed cell death through the activation of the caspase cascade. However, this process would be blocked if one of the proteins involved in executing apoptosis was genetically impaired or chemically inhibited, or if the apoptotic machinery was not properly oper...
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Necrosis is often viewed as an accidental and unregulated cellular event. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by regulated mechanisms. Hitomi et al. (2008) now describe an extensive network of genes that mediate a form of programmed necrosis called necroptosis.
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In contrast to the "programmed" nature of apoptosis and autophagy, necrotic cell death has always been believed to be a random, uncontrolled process that leads to the "accidental" death of the cell. This dogma, however, is being challenged and the concept of necrosis also being "programmed" is gaining ground. In particular, mitochondria appear to play a pivotal role in the mediation of programm...
متن کاملResearch Highlight RIP Kinases Initiate Programmed Necrosis
Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic ...
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The Persian Gulf and its shores are important and strategic areas with a large variety of fish species. Betanodavirus infection is known to be a serious threat to susceptible fish and causing economic damages to the fisheries and fishing industry. Concerning to isolation and confirmation of VNN virus in the Mullet fish (Chelon aurata and C. saliens) in the Caspian Sea and its damages on Mullet ...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2013
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2013.05.019